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Physician Bio

  • Sean Janzer, M.D.

    Prior to joining Einstein, Dr. Janzer was Chief of Interventional Services at Main Line Health System, and before that, he served as Director of Peripheral Interventions for Main Line Heart at Lankenau, Bryn Mawr and Paoli Hospitals.  He is board certified in Internal Medicine, Cardiovascular Disease, and Interventional Cardiology.

    Dr. Janzer offers expertise in advanced, minimally invasive treatments for heart and vascular conditions, including Peripheral Artery Disease (PAD), Critical Limb Ischemia, and coronary artery Chronic Total Occlusions (CTO).    

    He is skilled in the latest treatments for Peripheral Artery Disease (PAD), a condition that  involves a narrowing of the peripheral artery, reducing blood flow, most commonly in the arteries of the pelvis and legs, and in treating Critical Limb Ischemia, the most severe form of PAD.  Reduced blood flow is usually caused by atherosclerosis, or hardening of the arteries, which occurs when cholesterol and fat build-up and form plaque inside the arteries, causing them to narrow and clog.    

    Symptoms of PAD, which affects more than 12 million people, include leg pain at rest and/or when walking, wounds on the foot or toes that do not heal, gangrene, or a decrease in temperature of the leg or foot.  If a person has any of these symptoms they should be checked by a physician since early diagnosis and treatment greatly improves prognosis and quality of life.  

    If left untreated, PAD can lead to a heart attack or stroke, or amputation of the toe, foot or leg.  By using these innovative techniques, Dr. Janzer is able to prevent toe, foot and leg amputations in many patients.  

    Dr. Janzer and his team also treat coronary and peripheral artery Chronic Total Occlusions (CTO), a complete or nearly complete blockage of an artery, with a much less invasive procedure that involves the use of special guide wires and catheters to clear the athleroschlerotic blockages within the artery.  Prior to this advance, most patients with CTO required surgical intervention to clear the blockage in order to relieve chest pain, claudication (pain or weakness in the thigh, calf, and/or buttocks that occurs when walking, often causing the person to limp), or critical limb ischemia.       

    The following are two of the minimally invasive procedures Dr. Janzer offers patients: 

    Ocelot Image Guided Therapy 

    Dr. Janzer was one of the first interventional cardiologists in the Philadelphia region to use the Ocelot image guided therapy to treat blockages in the legs, using Optical Coherence Tomography (OCT).  The Ocelot uses ultrasound technology and involves threading a guide wire through the patient’s groin with a catheter at the end with a tiny drill and camera, making it possible for the doctor to see inside the artery.  The device shaves off plaque in the artery and opens up the blockage.

    The Ocelot is breakthrough technology because it is the first time doctors are able to see two-dimensional images from inside an artery to identify exactly where the plaque is located in order to remove it. The procedure, which takes about an hour, allows doctors to use less radiation and fluoroscopy (contrast dye) to open up the blockage.

    The Ocelot which is FDA-approved, brings the success rate for clearing leg blockages to greater than 90 percent.  “Patients now have an option other than bypass surgery which requires vein grafts and a much longer recovery,” says Dr. Janzer.  “But the best part of this treatment is that it restores people to a much better quality of life and saves so many from having to undergo an amputation.”


    A minimally invasive, catheter-based procedure that Dr. Janzer offers patients who need a new heart valve is the Transcatheter Aortic Valve Replacement (TAVR).  This procedure may be recommended for patients with severe narrowing of the aortic valve opening who are high-risk and not candidates for traditional open chest surgery.  To perform a TAVR, a catheter is placed in the femoral artery (in the groin) similar to angioplasty, and is guided into the chambers of the heart.  A compressed tissue heart valve is placed on the balloon catheter and is positioned directly inside the diseased aortic valve and the balloon is inflated to secure the valve in place. A team of interventional cardiologists, heart surgeons and cardiac anesthesiologists, work together to perform the TAVR procedure, utilizing fluoroscopy and echocardiography to guide the valve to the site of the patient’s diseased heart valve.        

     Conditions Treated

    Peripheral Artery Disease (PAD)

    Critical Limb Ischemia

    Coronary and Peripheral Artery Chronic Total Occlusions (CTO)


    Procedures and Therapies Provided

    Ocelot Image Guided Therapy 

    Transcatheter Aortic Valve Replacement (TAVR) 

    Percutaneous Coronary Angioplasty (PTCA) 

    Coronary Stent 


    Coronary Atherectomy 

    Coronary Rotablator

    To schedule an appointment with Dr. Janzer, call 215-456-8990. 

    Locations & Hours

    Hahnemann Medical College


    Hahnemann Medical College

    Medical School

    Hahnemann Medical College


    Hahnemann Medical College

    Teaching Appointment

    Albert Einstein Medical Center

    Board Certifications
    • Cardiology
    • Interventional Cardiology
    Takes Referrals for:
    • Cardiology
    • Interventional Cardiology
    • Peripheral Arterial Disease
    Areas of Interest
    • Cardiac Catheterization
    • Cardiovascular Diseases
    • Hypertension
    • Laser-Angioplasty
    • Peripheral Vascular Disease
  • Sean Janzer