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LOMITAPIDE is used in combination with diet and other medicines to lower blood cholesterol levels in patients with a genetic disorder that results in high blood cholesterol levels.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions:
if you often drink alcohol
an unusual or allergic reaction to lomitapide, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, at least 2 hours after your evening meal. Do not take with food. Do not cut, crush or chew this medicine. Do not take with grapefruit juice. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, the normal dose should be taken at the usual time the next day. If you miss your dose for more than a week, contact your doctor or healthcare professional before restarting treatment.
Do not take this medicine with any of the following medications:
calcium channel blockers like diltiazem and verapamil
certain antibiotics like ciprofloxacin, clarithromycin, erythromycin and telithromycin
certain antiviral medicines for HIV or AIDS
certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, and voriconazole
This medicine may also interact with the following medications:
birth control pills
certain medicines for blood pressure, heart disease, irregular heart beat
certain medicines for cholesterol like atorvastatin, lovastatin, simvastatin, cholestyramine, and colestipol
certain medicines for depression, anxiety, or psychotic disturbances
certain medicines for diabetes, like saxagliptin and sitagliptin
certain medicines for stomach problems like cimetidine and ranitidine
certain medicines that treat or prevent blood clots like warfarin, dabigatran, and ticagrelor
supplements like ginkgo biloba and goldenseal
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
To help prevent stomach problems while taking this medicine, you should stay on a low-fat diet. This medicine makes it harder for some nutrients to get into your body. You should take Vitamin E and fatty acids each day while you are taking this medicine. Talk to your doctor or healthcare provider about how to add these to your diet.
Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.
This medicine can cause liver injury. The risk of liver injury is increased in patients who drink alcohol while taking this medicine. Do not drink more than one alcoholic drink per day while taking this medicine.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
general ill feeling or flu-like symptoms
loss of appetite, nausea
right upper belly pain
unusually weak or tired
yellowing of the eyes or skin
Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.