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METHYSERGIDE (Sansert®) is one of a group of medicines known as ergot alkaloids. Methysergide helps to prevent certain kinds of throbbing headaches such as migraine and cluster headaches. It is not helpful once the headache has started. Generic methysergide tablets are not available.
NOTE: This drug is discontinued in the United States.
They need to know if you have any of these conditions:
heart or blood vessel disease
heart valve problems
systemic lupus (SLE)
an unusual or allergic reaction to methysergide, tartrazine dye, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Take methysergide tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Take methysergide with food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your prescriber's advice.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
If you miss a dose, skip that dose. Return to your normal schedule. Do not take double or extra doses.
Do not use any of the following migraine drugs within 24 hours of this medicine: almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, or zolmitriptan. Also, do not use this drug with caffeine-ergotamine combinations (example: Cafergot®, Wigraine®); dihydroergotamine (DHE®, Migranal®); ergotamine (example: Ergomar®); ergonovine; or methylergonovine (Methergine®).
Methysergide may also interact with the following drugs:
antibiotics such as erythromycin, clarithromycin, and troleandomycin
antifungal drugs like fluconazole, itraconazole, ketoconazole or voriconazole
ergoloid mesylates (Hydergine®)
herbal products like feverfew or guarana
medicines for colds, flu, or breathing difficulties
medicines for high blood pressure
medicines or herbal products to decrease weight or appetite
some medications for the treatment of HIV infection or AIDS
Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
Check with your prescriber or health care professional if you do not get relief from your headaches after the first 3 weeks.
It is important to tell your prescriber or health care professional as soon as you can if you get any of the following side effects: cold, numb, or painful hands or feet; leg cramps when walking; any type of pain around your chest, stomach or in your side.
Methysergide decreases the circulation of blood to your skin, fingers, and toes. You may get more sensitive to the cold. Elderly patients are more likely to feel this effect. Dress warmly and avoid long exposure to the cold.
You may get dizzy or drowsy. Do not drive, use machinery, or do anything that requires mental alertness until you know how methysergide affects you. To reduce the risk of dizzy or fainting spells, do not stand or sit up quickly.
Alcohol can make headaches worse or bring on a new headache. Therefore, you should avoid alcoholic drinks. Because smoking can increase side effects of methysergide, you should avoid smoking.
After 6 months of treatment, you must give your body a 3 to 4 week rest period without methysergide. Before you stop taking this medicine you must gradually reduce the dose over 2 to 3 weeks so that you do not get a headache rebound effect. Ask your prescriber or health care professional for a schedule.
If you are going to have any type of surgery, tell your prescriber or health care professional that you are taking methysergide.
Side effects that you should report to your prescriber or health care professional as soon as possible:
chest pain or tightness
cold hands or feet
confusion or hallucinations (hearing and seeing things that are not really there)
fast or pounding heartbeat
fever or chills
increase or decrease in the amount of urine passed
leg or arm pain or cramps
pain or difficulty passing urine
stomach pain, or pain in your side
swelling of hands, ankles, or feet
tingling, pain or numbness in feet or hands
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
dizziness or lightheadedness
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed.