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DIHYDROERGOTAMINE (dye hye droe er GOT a meen) is part of a group of medicines called ergot alkaloids. It is used to treat migraine headaches with or without aura. It should not be used to prevent migraine headaches.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions:
chest pain or difficulty breathing
heart or blood vessel disease
high blood pressure
risk factors for heart disease such as smoking, high cholesterol, a family history of heart disease, or if you are postmenopausal or a male over 40 years of age
an unusual or allergic reaction to dihydroergotamine, ergot alkaloids, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
This medicine is for use in the nose. Follow the directions on the prescription label. This medicine is given at the first symptoms of a migraine. It is not for everyday use. You must prepare the nasal spray only when you are ready to use it. Follow the instructions that come with your prescription or contact your doctor or health care professional if you are unsure how to do this. Throw away the sprayer after completing the full dose. Each unit is only good for eight hours once opened. Do not use this medicine more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
This does not apply; this medicine is not for regular use.
Do not take this medicine with any of the following medications:
antifungal drugs like fluconazole, itraconazole, ketoconazole or voriconazole
certain antibiotics like erythromycin, clarithromycin, and troleandomycin
medicines called nitrates like isosorbide and nitroglycerin
medicines for colds, flu, or breathing difficulties like phenylephrine and pseudoephedrine
medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan
other ergot alkaloids like bromocriptine, cabergoline, dihydroergotamine, ergoloid mesylates, ergonovine, methylergonovine, and methysergide
some medicines for HIV
This medicine may also interact with the following medications:
medicines for high blood pressure, especially beta-blockers
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Check with your doctor or health care professional if you do not get relief from your headaches after using this medicine. You may need to be changed to a different kind of medicine to treat your migraines.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can increase drowsiness, dizziness and flushing. Avoid alcoholic drinks.
This medicine decreases the circulation of blood to your skin, fingers, and toes. You may get more sensitive to the cold. Elderly patients are more likely to feel this effect. Dress warmly and avoid long exposure to the cold.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
cold hands or feet
fast, irregular heartbeat
leg or arm pain, cramps
swelling of hands, ankles, or feet
tingling, pain or numbness in feet or hands
weakness in legs
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
changes in the taste of food
nasal congestion or sore throat
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children.
Store at room temperature below 25 degrees C (77 degrees F). Protect from light, moisture, and heat. Do not refrigerate or freeze. Keep the parts of the nasal spray in the tray provided. Keep this tray loaded in the assembly case. Do not keep an opened nasal spray for more than 8 hours. Throw away any unopened medicine after the expiration date.
DIHYDROERGOTAMINE (dye hye droe er GOT a meen) is used to treat migraine headaches with or without aura. It should not be used to prevent migraine headaches.
blood vessel problems, or surgery on your arteries
risk factors for heart disease like smoking, high cholesterol, a family history of heart disease, or if you are a postmenopausal female or a male over 40 years of age
This medicine is for injection under the skin, into a muscle, or into a vein. You will be taught how to prepare and give this medicine. Use exactly as directed. Do not take your medicine more often than directed. Do not use more than the maximum daily or weekly dose. This drug is not for daily use.
It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.
This does not apply. Use this medicine only when you have a headache. Do not use double or extra doses.
Do not take this medicine with any of the following medicines:
ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
medicines used to treat colds or breathing difficulties
medicines used to treat fungal infections like itraconazole, ketoconazole, posaconazole and voriconazole
nitrate medicines like nitroglycerin
medicines for blood pressure
medicines for mental depression
Visit your doctor for regular check ups. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.
muscle pain or cramps
pain, tightness, or discomfort in your chest
pain, tingling, numbness in the hands or feet
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light, moisture, and heat. Do not refrigerate or freeze. Throw away any unused medicine after the expiration date.