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COBICISTAT; ELVITEGRAVIR; EMTRICITABINE; TENOFOVIR (koe BIS i stat; el vye TEG ra veer; em tri SIT uh bean; te NOE fo veer) is three antiretroviral medicines and a medication booster in one tablet. It is used to treat HIV. This medicine is not a cure for HIV. It will not stop the spread of HIV to others.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions:
an unusual or allergic reaction to cobicistat, elvitegravir, emtricitabine, tenofovir, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Do not take this medicine with any of the following medications:
medicines for cholesterol like lovastatin, simvastatin
medicines for headaches like dihydroergotamine, ergotamine, methylergonovine
other antiviral medicines for HIV or AIDS
St. John's wort
This medicine may also interact with the following medications:
certain antibiotics like clarithromycin, telithromycin, rifabutin, rifapentine
certain medications for anxiety or sleep like buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem
certain medicines for depression, anxiety, or psychiatric disturbances
certain medicines for erectile dysfunction like tadalafil, vardenafil
certain medicines for fungal infection like itraconazole, ketoconazole, voriconazole
certain medicines for seizures like carbamazepine, clonazepam, ethosuximide, oxcarbazepine, phenobarbital, phenytoin
female hormones, like estrogens and progestins and birth control pills
medicines for infection like acyclovir, cidofovir, valacyclovir, ganciclovir, valganciclovir
medicines for irregular heart beat like amiodarone, bepridil, digoxin, disopyramide, dofetilide, flecainide, lidocaine, mexiletine, propafenone, quinidine
phenothiazines like perphenazine, risperidone, thioridazine
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.
HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.
If you have hepatitis B, talk to your doctor if you plan to stop this medicine. The symptoms of hepatitis B may get worse if you stop this medicine.
Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. Women who can still have children must use a reliable form of barrier contraception, like a condom.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
general ill feeling or flu-like symptoms
loss of appetite
nausea, vomiting, unusual stomach upset or pain
right upper belly pain
trouble passing urine or change in the amount of urine
unusually weak or tired
yellowing of the eyes or skin
Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):
skin discoloration on the hands or feet
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.