Skip to main content
More Search Options
A member of our team will call you back within one business day.
ACETAMINOPHEN; ASPIRIN; CAFFEINE (a set a MEE noe fen; AS pir in; KAF een) is a pain reliever. It is used to treat mild aches and pains. This medicine may help with arthritis, colds, headache (including migraine), muscle aches, menstrual cramps, sinusitis, and toothache.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions:
anxiety or panic attacks
child with chickenpox, the flu, or other viral infection
high blood pressure
if you frequently drink alcohol containing drinks
low level of vitamin K
stomach ulcers or other problems
an unusual or allergic reaction to acetaminophen, aspirin, caffeine, other medicines, foods, dyes or preservatives
pregnant or trying to get pregnant
Take this medicine by mouth. Place one packet of powder on tongue and follow with plenty of liquid, or stir powder into a glass of water or other liquid. Follow the directions on the package or prescription label. You can take this medicine with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take your medicine more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Patients over 65 years old may have a stronger reaction and need a smaller dose.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Do not take this medicine with any of the following medications:
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
other medicines with acetaminophen
This medicine may also interact with the following medications:
herbal supplements like feverfew, garlic, ginger, ginkgo biloba, horse chestnut
medicines for diabetes or glaucoma like acetazolamide, methazolamide
medicines for gout
medicines that stimulate or keep you awake
medicines that treat or prevent blood clots like enoxaparin, heparin, ticlopidine, warfarin
NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
other aspirin and aspirin-like medicines
some cough and cold medicines like pseudoephedrine
varicella live vaccine
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Tell your doctor or health care professional if the pain lasts more than 10 days, if it gets worse, or if there is a new or different kind of pain. Tell your doctor if you see redness or swelling. If you are treating a fever, check with your doctor if the fever that lasts for more than 3 days.
Do not take Tylenol (acetaminophen) or medicines that have acetaminophen with this medicine. Too much acetaminophen can be very dangerous. Always read medicine labels carefully.
Report any possible overdose to your doctor or health care professional right away, even if there are no symptoms. The effects of extra doses may not be seen for many days.
This medicine can irritate your stomach or cause bleeding problems. Do not smoke cigarettes or drink alcohol. Do not lie down for 30 minutes after taking this medicine to prevent irritation to your throat.
If you are scheduled for any medical or dental procedure, tell your healthcare provider that you are taking this medicine. You may need to stop taking this medicine before the procedure.
Do not take this medicine close to bedtime. It may prevent you from sleeping.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
black, tarry stools
fast, irregular heartbeat
feeling faint or lightheaded, falls
fever or sore throat
pain on swallowing
ringing in the ears or trouble hearing
trouble passing urine or change in the amount of urine
unusual bleeding or bruising
unusually weak or tired
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
passing urine more often
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.
Take this medicine by mouth with a glass of water. Follow the directions on the package or prescription label. You can take this medicine with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take your medicine more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years for selected conditions, precautions do apply.