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PROBUCOL (Lorelco®) was used to block the body's ability to make cholesterol. This drug lowered blood fats and cholesterol for patients who are at risk of getting heart disease or a stroke.
NOTE: This drug is discontinued in the United States.
They need to know if you have any of these conditions:
low levels of blood potassium or magnesium
an unusual or allergic reaction to probucol, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Take probucol tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. It is best to take probucol with food, take with morning and evening meals if you take the tablets twice a day. Take your doses at regular intervals. Do not take your medicine more often than directed.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
beta-blockers, often used for high blood pressure or heart problems
medicines to control heart rhythm
medicines for mental depression
medicines for mental problems and psychotic disturbances
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
Probucol will not cure your condition, but taken regularly it will help keep down your cholesterol level. Visit your prescriber or health care professional for regular checks on your progress. Do not stop taking probucol, except on your prescriber's advice.
Probucol is only part of a total cholesterol-lowering program. Your physician or dietician can suggest a low-cholesterol and low-fat diet that will reduce your risk of getting heart and blood vessel disease. Avoid alcohol and smoking, and keep a proper exercise schedule.
If you are going to have surgery tell your prescriber or health care professional that you are taking probucol.
You may get dizzy; until you know how probucol affects you, do not drive, use machinery, or do anything that needs mental alertness. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can make you more dizzy, increase flushing and rapid heartbeats; avoid alcoholic drinks.
Side effects that you should report to your prescriber or health care professional as soon as possible:
fast or irregular heartbeats (palpitations)
muscle aches or cramps
unusual bleeding or bruising
unusual tiredness or weakness
unusual swelling of the face, tongue, lips, hands or feet
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
upset stomach, gas, or heartburn
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.