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LERCANIDIPINE (Lastolic™, Zanidip®) is a calcium-channel blocker. It relaxes blood vessels, which can lower blood pressure and reduce the amount of work the heart has to do. Lercanidipine reduces blood pressure and may reduce attacks of chest pain if you have angina. It is not a cure. Generic lercanidipine tablets are not available.
They need to know if you have any of these conditions:
heart valve problems such as aortic stenosis
low blood pressure
persistent chest pain
previous heart attack
slow or irregular heartbeat
an unusual reaction to lercanidipine, dihydropyridine-type calcium channel blockers (examples: amlodipine, nifedipine), other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Take lercanidipine tablets by mouth. Follow the directions on the prescription label. Swallow the tablets whole with a drink of water. Do not take lercanidipine with grapefruit juice or with a high-fat meal. Take your doses at regular intervals. Do not take your medicine more often then directed. Do not stop taking except when advised by your prescriber.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
antiinflammatory drugs (NSAIDs, such as ibuprofen)
barbiturates such as phenobarbital
herbal or dietary supplements such as ginger, ginkgo biloba, ginseng, hawthorn, ma huang (ephedra), melatonin, St. John's wort, red yeast rice
local anesthetics or general anesthetics
medicines for fungal infections (fluconazole, itraconazole, ketoconazole, voriconazole)
medicines for high blood pressure
medicines for HIV infection or AIDS
medicines for prostate problems
medicines for seizures (carbamazepine, phenobarbital, phenytoin, primidone, zonisamide)
monoamine oxidase inhibitors (Azilect®, Eldepryl®, Emsam®, Marplan®, Nardil®, Parnate®, Zelapar™)
rifampin, rifapentine, or rifabutin
some antibiotics (clarithromycin, erythromycin, telithromycin, troleandomycin)
some medicines for heart-rhythm problems (amiodarone, diltiazem, verapamil)
some medicines for depression or mental problems (fluoxetine, fluvoxamine, nefazodone)
water pills (diuretics)
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
Check your blood pressure and pulse rate regularly; this is important while you are taking lercanidipine. Ask your prescriber or health care professional what your blood pressure and pulse rate should be and when you should contact him or her.
You may feel dizzy or lightheaded. Do not drive, use machinery, or do anything that needs mental alertness until you know how lercanidipine affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Avoid alcoholic drinks; they can make you more dizzy, increase flushing and rapid heartbeats.
Do not suddenly stop taking lercanidipine. Ask your prescriber or health care professional how you can gradually reduce the dose.
If you are going to have surgery, tell your prescriber or health care professional that you are taking lercanidipine.
Side effects that you should report to your prescriber or health care professional as soon as possible:
fainting spells, dizziness or lightheadedness
irregular heartbeat, chest pain, palpitations
swelling of the legs or ankles
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.