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MIBEFRADIL (Posicor®) is a calcium-channel blocker that was used for high blood pressure and chest pain.
NOTE: This drug is discontinued in the United States.
They need to know if you have any of these conditions:
coronary artery disease
low blood pressure
an unusual or allergic reaction to mibefradil, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Take mibefradil tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. You can take the tablets with or without food. Take your doses at regular intervals. Do not take your medicine more often then directed. Do not stop taking except on your prescriber's advice.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
antiinflammatory drugs (NSAIDs, such as ibuprofen)
barbiturates such as phenobarbital
certain antibiotics (clarithromycin, erythromycin, norfloxacin, telithromycin, troleandomycin)
certain medicines used to treat cancer
herbal or dietary supplements such as ginkgo biloba, ginseng, hawthorn, ma huang (ephedra), melatonin, St. John's wort, red yeast rice
local anesthetics or general anesthetics
medicines for anxiety or difficulty sleeping (examples: alprazolam, buspirone, midazolam, triazolam)
medicines for depression or mental problems
medicines for fungal infections (fluconazole, itraconazole, ketoconazole, voriconazole)
medicines for heart-rhythm problems
medicines for high cholesterol (atorvastatin, cerivastatin, lovastatin, simvastatin)
medicines for high blood pressure or heart problems
medicines for HIV infection or AIDS
medicines for prostate problems
medicines for seizures
monoamine oxidase inhibitors (Azilect®, Eldepryl®, Emsam®, Marplan®, Nardil®, Parnate®, Zelapar™)
rifampin, rifabutin or rifapentine
water pills (diuretics)
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
Check your blood pressure and pulse rate regularly; this is important while you are taking mibefradil. Ask your prescriber or health care professional what your blood pressure and pulse rate should be and when you should contact him or her.
You may feel dizzy or lightheaded. Do not drive, use machinery, or do anything that needs mental alertness until you know how mibefradil affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Avoid alcoholic drinks because they can make you more dizzy, increase flushing, and cause rapid heartbeats.
Do not suddenly stop taking mibefradil. Ask your prescriber or health care professional how you can gradually reduce the dose.
If you are going to have surgery, tell your prescriber or health care professional that you are taking mibefradil.
Side effects that you should report to your prescriber or health care professional as soon as possible:
Rare or uncommon:
fainting spells, lightheadedness
irregular heartbeat, chest pain, palpitations
swelling of legs and ankles
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
drowsiness or dizziness
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.