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RETEPLASE (RE te plays) is used to dissolve blood clots that form in certain blood vessels. This medicine is used when a blood clot in a heart artery causes a heart attack.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions:
bleeding problems or problems with blood clotting
diabetic retinopathy or bleeding problems of the eye
endocarditis (infection of the heart valves)
head injury, brain disease, or tumor
high blood pressure
recent biopsy, childbirth, surgery, or trauma (injury)
recent history of stroke
stomach ulcer or bleeding ulceran unusual or allergic reaction to reteplase, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
This medicine is for injection into a vein. It is usually given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
This does not apply.
Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
antiplatelet drugs such as ticlopidine or clopidogrel
aspirin and aspirin-like drugs
medicines that treat or prevent blood clots like warfarin, heparin, enoxaparin, and dalteparin
NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
You will be closely monitored to check your progress after you receive this medicine. Follow the advice of your doctor or health care professional exactly. You may need bed rest to minimize the risk of bleeding.
This medicine can make you bleed more easily. This effect can last for several days. Try to avoid damage to your teeth and gums when you brush or floss your teeth, and try to avoid any other injury to yourself.
Do not take aspirin, ibuprofen, or other nonprescription pain relievers during or for several days after treatment with this medicine unless otherwise told to do so by your doctor or health care professional.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
blood in the urine, stools, or vomit
chest pain or tightness
constipation or black tarry stools
slow or fast heart rate
unusual bleeding or bruising
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
This drug is given in a hospital or clinic and will not be stored at home.